Explanation

Correct Answer: Use a combination of CloudHub-deployed and manually provisioned on-premises Mule runtimes managed by the MuleSoft-hosted Platform control plane.

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Key details to be taken from the given scenario:

>> Organization uses BOTH cloud-based and on-premises systems

>> On-premises systems can only be accessed from within the organization's intranet

Let us evaluate the given choices based on above key details:

>> CloudHub-deployed Mule runtimes can ONLY be controlled using MuleSoft-hosted control plane. We CANNOT use Private Cloud Edition's control plane to control CloudHub Mule Runtimes. So, option suggesting this is INVALID

>> Using CloudHub-deployed Mule runtimes in the shared worker cloud managed by the MuleSoft-hosted Anypoint Platform is completely IRRELEVANT to given scenario and silly choice. So, option suggesting this is INVALID

>> Using an on-premises installation of Mule runtimes that are completely isolated with NO external network access, managed by the Anypoint Platform Private Cloud Edition control plane would work for On-premises integrations. However, with NO external access, integrations cannot be done to SaaS-based apps. Moreover CloudHub-hosted apps are best-fit for integrating with SaaS-based applications. So, option suggesting this is BEST WAY.

The best way to configure and use Anypoint Platform to support these mixed/hybrid integrations is to use a combination of CloudHub-deployed and manually provisioned on-premises Mule runtimes managed by the MuleSoft-hosted Platform control plane.