Isolating the impacted endpoints is the best course of action for the information security manager after an employee clicked on a link in a phishing email, triggering a ransomware attack because it prevents the ransomware from spreading to other systems or devices on the network, and minimizes the damage or disruption caused by the attack. Wiping the affected system is not a good course of action because it may destroy any evidence or data that could be used for investigation or recovery. Notifying internal legal counsel is not a good course of action because it does not address the immediate threat or impact of the ransomware attack. Notifying senior management is not a good course of action because it does not address the immediate threat or impact of the ransomware attack. References: https://www.isaca.org/resources/isaca-journal/issues/2017/volume-5/incident-response-lessons-learned https://www.isaca.org/resources/isaca-journal/issues/2018/volume-3/incident-response-lessons-learned