The primary benefit of using one-time passwords is that an intercepted password cannot be reused, as it is valid only for a single login session or transaction. One-time passwords enhance the security of authentication by preventing replay attacks or password guessing. The other options are not the primary benefits of using one-time passwords. Security for applications can be automated with or without one-time passwords. Users may still have to memorize complex passwords or use a device or software to generate one-time passwords. Users can still be locked out of an account if they enter an incorrect or expired one-time password. References: CISA Review Manual (Digital Version), Chapter 6, Section 6.1