For latency-sensitive, globally distributed applications such as online gaming, minimizing network latency between users and application endpoints is critical. AWS Global Accelerator is designed specifically for this purpose. It uses the AWS global network and Anycast IP addresses to route user traffic to the closest healthy endpoint, reducing latency and improving performance for users worldwide.

Option C is the best solution because Global Accelerator directs traffic over the AWS backbone network instead of the public internet, which significantly reduces jitter and latency. It also provides built-in health checks and automatic failover, improving availability as the service expands globally. Importantly, Global Accelerator works seamlessly with existing Application Load Balancers, allowing the company to enhance performance without redesigning the application stack.

Option A (CloudFront) is optimized for caching static and cacheable content and is not ideal for real-time, stateful gaming traffic. Option B adds unnecessary API abstraction and additional latency. Option D introduces regional duplication and DNS-based routing, which is slower to react to network conditions and does not provide the same low-latency routing as Global Accelerator.

Therefore, C meets the requirement for global expansion with the least possible latency while maintaining a simple and highly performant architecture.