Diabetes insipidus (DI) results from insufficient antidiuretic hormone (ADH), leading to polyuria and dehydration. Management involves fluid replacement to correct volume loss and administration of vasopressin (or desmopressin) to replace deficient ADH.
“Central DI is treated with fluid resuscitation to manage hypovolemia and administration of vasopressin or desmopressin to reduce urinary losses and restore water balance.”
(Referenced from CCRN Pediatric – Direct Care: Endocrine, Water Balance Disorders)
Aldosterone is not indicated in the treatment of central DI. Restriction of fluids is contraindicated, as the patient is losing large volumes of free water.
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