To design a report definition that sorts cases so that the case with the most recent create date appears at the top of the list and descends in order, the sorting of the Create Date column must be configured appropriately.

C. Select Highest to Lowest sort type for Create Date: This sorting option ensures that the report organizes the cases starting with the most recent (highest) create date first, descending to the earliest (lowest) create date. This configuration aligns directly with the manager's requirement to have the most recently created cases at the top of the report, facilitating quick access to the latest cases.

Selecting Lowest to Highest sort type for Create Date (A) would result in the opposite of the requested order, placing the oldest cases at the top. Adding a filter condition where Create Date is greater than the current date (B) wouldn't be practical, as create dates cannot be in the future. Making the Create Date the first column in the report (D) might aid in readability but on its own does not ensure the correct sorting order.