Calm can be deployed as a VM on ESXi or AHV hypervisors and leverage calm functionality without the Nutanix infrastructure. Calm can also be enabled inside of Prism Central, which is a VM that can run on any Nutanix supported hypervisor, including ESXi and AHV. However, Calm cannot be enabled inside of Prism Element, which is the management interface for each Nutanix cluster. Calm also cannot be deployed as a VM on Hyper-V, as this is not a supported hypervisor for Calm. References: Nutanix Calm Configuration and Training, Calm on ESXi Deployment | Nutanix Community, Nutanix Support & Insights
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