The therapeutic index is the ratio between the median lethal dose and median effective dose of a drug. It
provides a general indication of the margin of safety of a drug. Choice 1 is incorrect because pharmacokinetics
is the process of adsorption, distribution, metabolism, and elimination. Choice 2 is incorrect because narrow
therapeutic index drugs require close monitoring since there is often little difference between the desired drug
effect and toxicity. Choice 4 is incorrect because narrow therapeutic index drugs have the potential for severe
toxic effects with only slight increases in the dose or slight decreases in elimination.Pharmacological Therapies
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