Only an unbound drug can be distributed to active receptor sites. Therefore, the more of a drug that is bound
to protein, the less it is available for the desired drug effect. Choice 1 is incorrect because less drug is available if
it is bound to protein. Choice 2 is incorrect because distribution to receptor sites is irrelevant if the drug, which is
bound to protein, cannot bind with a receptor site. Choice 4 is incorrect because metabolism is not increased. The
liver first has to remove the drug from the protein molecule before metabolism can occur. The protein is then free
to return to circulation and be used again.Pharmacological Therapies
Contribute your Thoughts:
Chosen Answer:
This is a voting comment (?). You can switch to a simple comment. It is better to Upvote an existing comment if you don't have anything to add.
Submit