To best achieve a low rate of harm in spite of inherent risks in healthcare, an organization must apply principles of high reliability123. High reliability organizations (HROs) operate under challenging conditions yet experience fewer problems than would be anticipated. They have cultures that are preoccupied with the possibility of failure, reluctant to simplify interpretations, sensitive to operations, committed to resilience, and deference to expertise1.

In healthcare, this means standardizing processes, such as for cleaning instruments, patient identification, communication handovers1. It also involves analyzing incidents of harm or near misses, and empowering staff to report potential unsafe situations1. Performance is measured, benchmarked against reliable standards, and goals are set for improvement1.

Therefore, the answer is option D: apply principles of high reliability. This approach is more comprehensive and effective in achieving a low rate of harm in healthcare, as it addresses the complexity and variability in healthcare processes and outcomes23.