Fibrocystic change is the most common benign breast condition in women of reproductive age. It typically presents with diffuse nodularity or " lumpy " areas, especially in the upper outer quadrant, and varies with the menstrual cycle. No dominant mass or systemic signs are expected.

Toronto Notes 2023 – Gynecology, “Benign Breast Conditions”:

“Fibrocystic changes often present with bilateral or unilateral nodularity, most commonly in the upper outer quadrants, without discrete masses.”

MCCQE1 Objectives (Gynecology > 81-1: Breast Conditions):

“Candidates must differentiate benign breast conditions from malignant ones based on presentation and physical exam findings.”

Paget disease (B) presents with nipple changes. Intraductal carcinoma (C) typically shows a discrete mass or suspicious features. Phyllodes tumours are usually well-circumscribed. Mastitis (E) is inflammatory and associated with erythema, fever, and tenderness.