Whenever you run into audiences that have a high overlap, you should always merge both of them into one. If you run both audiences under the same campaign, you will have multiple ad sets competing against each other. 

If you have never used Facebook’s audience overlap tool, you can find it on Facebook’s Ads Manager and follow the next steps:

Click on the Tools drop-down menu and choose Audience.

Once there, select the audiences you want to compare, click on the Actions tab, and choose Show Audience Overlap.

You can select multiple audiences, but you will only be able to compare one against the other at a time.In the tool, you will be able to see the number and percentage of overlapping members between them.

A second option is to completely change one of the audiences so that there is less than 25% overlap between both audiences. 

In this case, you could change audience #1 interests to something different but still related to your target market to have two potential audiences to use.