Comprehensive and Detailed Explanation From Exact Extract:

Endpoint protection systems rely on policy rules, signatures, behavioral analytics, and heuristics. When the analyst identifies the event as a false positive, this indicates the file itself was not malicious, but the endpoint protection solution incorrectly identified it as a threat. According to CompTIA Security+ SY0-701 concepts, false positives commonly occur due to overly aggressive configuration settings, outdated rules, unrefined behavioral baselines, or incorrect threat signatures.

Zero-day vulnerabilities (B) would cause a true positive because the file contains unknown malware, not a false alert. A supply chain attack (C) would impact the vendor or update delivery, not a user download event. Incorrect file permissions (D) prevent access but do not trigger malware alerts.

Misconfigurations are identified in SY0-701 under Security Operations → Monitoring, alerting, tuning, and false positives, which emphasizes the need for refining security controls to reduce erroneous blocks. Therefore, the most likely cause of a blocked benign download is a misconfigured endpoint protection policy.