A Simple Custom Detection List is a feature of Cisco AMP for Endpoints that allows administrators to create a list of SHA-256 hashes of files that they want to detect, block, and quarantine on their endpoints. The list can be applied to a policy and the connectors will synchronize with the latest changes. However, the list only works with the exact SHA-256 hashes that are provided, and it does not detect any variations or modifications of the files. Therefore, if the malicious file abc428565580xyz.exe has been altered in any way, such as by changing its name, size, or content, the Simple Custom Detection List will not be able to recognize it as a threat. To ensure detection of the malicious file, the administrator must upload the SHA-256 hash of the current version of the file to the Simple Custom Detection List, or use another method that can detect file variations, such as an Advanced Custom Detection List or Cisco Threat Grid. References :=

Some possible references are:

Configure a Simple Custom Detection List on the AMP for Endpoints Portal

Create an Advanced Custom Detection List in Cisco Secure Endpoint

[Cisco AMP for Endpoints User Guide]

https://www.cisco.com/c/en/us/td/docs/security/firepower/amp/6-3/user-guide/amp-user-guide.pdf