According to the User Guide for AsyncOS 12.0 for Cisco Email Security Appliances2, the order of virus scanning when multilayer antivirus scanning is configured is as follows:
The McAfee engine scans the message first. If the McAfee engine detects a virus, the message is dropped or repaired, depending on the configuration. If the McAfee engine does not detect a virus, the message is passed to the next layer of scanning.
The Sophos engine scans the message second. If the Sophos engine detects a virus, the message is dropped or repaired, depending on the configuration. If the Sophos engine does not detect a virus, the message is delivered to the recipient.
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