In a REST API, operations are performed on an object (node) that is identified by a URL, but RPC APIs are operation-oriented.

In a REST API, operations are performed on an external resource that is defined on the API, but the RCP APIs are resource-oriented.

In a REST API, operations are performed on a platform that is identified by the URL, but RPC APIs are platform-oriented.

In a REST API, operations are performed on an internal resource that is defined on the API, but RPC APIs are resource-oriented.