A patient with pertussis (whooping cough) should remain on Droplet Precautions to prevent transmission. According to APIC guidelines, patients with pertussis can be removed from Droplet Precautions after completing at least five days of appropriate antimicrobial therapy and showing clinical improvement.

Why the Other Options Are Incorrect?

A. Direct fluorescent antibody and/or culture are negative – Laboratory results may not always detect pertussis early, and false negatives can occur.

C. The patient has been given pertussis vaccine – The vaccine prevents but does not treat pertussis, and it does not shorten the period of contagiousness.

D. The paroxysmal stage has ended – The paroxysmal stage (severe coughing fits) can last weeks, but infectiousness decreases with antibiotics.

CBIC Infection Control Reference

According to APIC guidelines, Droplet Precautions should continue until the patient has received at least five days of antimicrobial therapy​.