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American Society of Microbiology ABMM ABMM Question # 95 Topic 5 Discussion

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American Society of Microbiology ABMM ABMM Question # 95 Topic 5 Discussion

ABMM Exam Topic 5 Question 95 Discussion:
Question #: 95
Topic #: 5

A clinical isolate of Klebsiella pneumoniae from a patient with a refractory urinary tract infection exhibits resistance to carbapenems (imipenem, meropenem, ertapenem). PCR analysis reveals the presence of the blaKPC gene. Which of the following enzymatic mechanisms is responsible for this resistance?
A.

Hydrolysis of the beta-lactam ring, leading to an inactive antibiotic derivative.

B.

Modification of the ribosomal target site, preventing antibiotic binding.

C.

Efflux of the carbapenem antibiotic out of the bacterial cell.

D.

Trapping of the carbapenem molecule by a decoy protein.

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Actual exam question for American Society of Microbiology ABMM exam by Nyx46575 at Aug 2, 2025, 12:00:00 AM

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