Sterile probe covers with sterile coupling gel can be employed during intra-articular injections, particularly those that require close proximity between the transducer and the needle tip.

The needle can touch the uncovered probe during the procedure as long as sterile gel is used.

Not using probe covers during ultrasound-guided arthrocentesis has been demonstrated to lead to increased rates of joint infections.

Povidone iodine swab of the injection site has been demonstrated to be insufficient to minimize infection during ultrasound-guided arthrocentesis.