Create a connection alias in the primary Region and in the failover Region. Associate each with a directory in its Region. Create a Route 53 failover routing policy with Evaluate Target Health = Yes.

Create a connection alias in both Regions. Associate both with a directory in the primary Region. Use a Route 53 multivalue answer routing policy.

Create a connection alias in the primary Region. Associate with the directory in the primary Region. Use Route 53 weighted routing.

Create a connection alias in the primary Region. Associate it with the directory in the failover Region. Use Route 53 failover routing with Evaluate Target Health = Yes.