While CPU/memory impactoverall NSX performance,they do not determine uplink/transport profile design.
(C - Number of VMs Per Host):
VM density affects overlay traffic, butuplink profile design depends on NIC configuration.
(D - Physical Location of ESXi Hosts):
Location is important for high availability, but it does notdirectly define uplink profiles.
VMware NSX 4.x Reference:
NSX-T Uplink Profile & Transport Zone Design Guide
NIC Performance Optimization for NSX-T
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