You can exclude a material from the MRP run by using a specific material status or a specific MRP type. A material status is a user-defined indicator that can be assigned to a material master record to control the procurement and planning activities for the material. For example, you can define a material status that blocks the material from being planned by MRP. An MRP type is a parameter that defines how a material is planned by MRP. For example, you can use the MRP type ND (No Planning) to exclude the material from the MRP run.
References: [SAP S/4HANA Production Planning and Manufacturing Certification Guide], page 87; [SAP Help Portal: Material Status] and [SAP Help Portal: MRP Type].
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