TheM-M-R II (Measles, Mumps, and Rubella) vaccinemust bereconstituted only with the manufacturer-supplied diluentto maintain its efficacy and stability.
The manufacturer-provided diluent contains stabilizing agents that preserve the live attenuated virus.
Using normal saline can alter the pH and degrade the vaccine, making it ineffective.
The vaccine must be discarded if reconstituted incorrectlyand not administered.
A. Administer the vaccine as the diluents are equivalent.❌→Incorrect
Normal saline is NOT equivalent to the manufacturer’s diluentand can compromise the vaccine’s potency.
B. Report the incident to the Drug Enforcement Administration (DEA).❌→Incorrect
Vaccine errors should be reported to the CDC’s Vaccine Adverse Event Reporting System (VAERS), not the DEA(which handles controlled substances, not vaccines).
C. Contact the Environmental Protection Agency (EPA) for guidance.❌→Incorrect
The EPA regulates hazardous waste, not vaccine errors.The CDC or vaccine manufacturer should be contacted for guidance.
CDC Vaccine Storage and Handling Guidelines– States thatvaccines must be reconstituted only with manufacturer-supplied diluents.
FDA Guidelines for M-M-R II Vaccine– Confirms that improper reconstitutionrenders the vaccine ineffective.
Why Is Normal Saline Not an Acceptable Diluent?Why Not the Other Options?Key References:
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