Cefdinir is a cephalosporin (β-lactam) antibiotic. Patients with a penicillin allergy can have cross-reactivity with cephalosporins due to similar β-lactam structures, although the risk is lower with later generations like cefdinir. Because of this known potential cross-sensitivity, it is standard practice to assess for penicillin allergy when dispensing cephalosporins. Option A is incorrect because penicillin allergy is not an absolute, specific contraindication to cefdinir in all cases; risks must be assessed. Option B is incorrect (fluoroquinolones are unrelated class). Option D is overly general and not a standard rationale.
• PTCB/ExCPT study materials on antibiotic classes and allergy cross-reactivity (β-lactams: penicillins and cephalosporins).
• ISMP medication safety guidance on allergy screening and β-lactam cross-sensitivity.
• Community pharmacy counseling references on assessing penicillin allergies before dispensing cephalosporins.
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