TheNational Institute for Occupational Safety and Health (NIOSH)publishes a list ofhazardous drugsthat require pharmacy staff to wear appropriatepersonal protective equipment (PPE)when handling.Megestrol (Megace) and Dutasteride (Avodart)are both classified as hazardous drugs due to their potentialteratogenic and reproductive toxicity risks.
Megestrolis aprogestinused for appetite stimulation in cancer and HIV patients. It poses arisk to pregnant healthcare workersdue to potential hormonal effects.
Dutasterideis a5-alpha reductase inhibitorused forbenign prostatic hyperplasia (BPH). It can beabsorbed through the skinand iscontraindicated in women of childbearing potentialdue to the risk offetal abnormalities.
Wear gloveswhen handling uncoated tablets or broken tablets.
Use respiratory protectionif there is a risk of airborne particles.
B. Furosemide and buspirone→ Incorrect; these arenot classified as hazardous drugsby NIOSH.
C. Glyburide and acetazolamide→ Incorrect; these arenot hazardous drugsrequiring PPE.
D. Glipizide and zolpidem→ Incorrect; these medications arenot hazardousper NIOSH guidelines.
NIOSH PPE Recommendations:Other Answer Choices Explained:References:
NIOSH List of Hazardous Drugs in Healthcare Settings (2020 Update)
USP <800> Hazardous Drug Handling in Healthcare Settings
PTCB PTCE Exam Content Outline (Medication Safety and Hazardous Drug Handling)
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