Based on the provided Pareto chart of general surgery readmission causes, the most significant causes should be addressed first to have the greatest impact on reducing readmissions.

Pareto Principle (80/20 Rule): The chart illustrates that a small number of causes contribute to the majority of the readmissions. The top three causes—pain, constipation, and PCP (Primary Care Provider) unavailable—account for the most significant portion of the readmissions.

Prioritization of Interventions: By addressing these top three causes first, thehealthcare team can potentially prevent the majority of readmissions, making the intervention more efficient and effective.

Strategic Focus: Focusing on pain, constipation, and the unavailability of PCPs aligns with the principle of focusing on the "vital few" causes rather than spreading resources thinly across many less significant issues.