In the context of Microsoft Dynamics 365 Business Central, an extension may not appear in the tenant for several reasons, particularly after an upgrade to a new major version.

Option A suggests that the extension was published as a DEV extension, which typically would not cause it to disappear after an upgrade because DEV extensions are intended for development and testing within sandbox environments.

Option B indicates that the extension was not compatible with the new version within 60 days of the first notification. This is a likely reason because Microsoft enforces compatibility rules, and extensions that are not made compatible within the specified timeframe might be removed or disabled.

Option C refers to the extension being published as a PTE (Per-Tenant Extension) and mentions the Platform parameter not being updated. This could cause issues, but not specifically the disappearance of the extension after an upgrade.

Option D expands on Option C by adding that both the Platform and Runtime parameters were not updated in the application file. This is a critical aspect because if these parameters are not correctly set to indicate compatibility with the new version of Business Central, the extension could be disabled or removed.

Option E is similar to Option B but mentions a 90-day period. This option does not align with standard Business Central practices for version compatibility requirements.

Therefore, the two possible reasons for the disappearance of the extension in the tenant after an upgrade are that the extension was not compatible with the new version within the required timeframe (Option B) and that the extension was published as a PTE without the Platform and Runtime parameters being updated (Option D).