American Society of Microbiology ABMM ABMM Question # 92 Topic 5 Discussion

American Society of Microbiology ABMM ABMM Question # 92 Topic 5 Discussion

ABMM Exam Topic 5 Question 92 Discussion:
Question #: 92
Topic #: 5

A research laboratory is investigating the mechanism of action of a novel antiviral compound. In vitro studies demonstrate that the compound effectively inhibits the replication of a specific enveloped RNA virus. Further analysis reveals that the compound does not interfere with viral entry, genome replication, or protein synthesis. However, electron microscopy of infected cells treated with the compound shows an accumulation of viral glycoproteins within the endoplasmic reticulum and Golgi apparatus, with a significant reduction in the release of infectious virions. The MOST likely target of this antiviral compound is:


A.

Viral RNA-dependent RNA polymerase


B.

Viral protease responsible for polyprotein cleavage


C.

Host cell membrane fusion machinery


D.

Viral glycoprotein trafficking and maturation


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