To securely use large language models (LLMs) on Amazon Bedrock, companies should design clear and specific prompts to avoid unintended outputs and ensure proper configuration of AWS Identity and Access Management (IAM) roles and policies with the principle of least privilege. This approach limits access to sensitive resources and minimizes the potential impact of security incidents.

Option A (Correct): "Design clear and specific prompts. Configure AWS Identity and Access Management (IAM) roles and policies by using least privilege access": This is the correct answer as it directly addresses both security practices in prompt design and access management.

Option B: "Enable AWS Audit Manager for automatic model evaluation jobs" is incorrect because Audit Manager is for compliance and auditing, not directly related to secure LLM usage.

Option C: "Enable Amazon Bedrock automatic model evaluation jobs" is incorrect because Bedrock does not provide automatic model evaluation jobs specifically for security purposes.

Option D: "Use Amazon CloudWatch Logs to make models explainable and to monitor for bias" is incorrect because CloudWatch Logs are used for monitoring and not directly for making models explainable or secure.

AWS AI Practitioner References:

Secure AI Practices on AWS: AWS recommends configuring IAM roles and using least privilege access to ensure secure usage of AI models.